Investigators create “brain map” of key epigenetic processes
August 14, 2012
Epigenetics, the study of how the environment modifies the way the human gene is expressed, is an emerging frontier in science. Diet and exposure to environmental chemicals, among other factors, can cause epigenetic changes that may turn...
Experimental Alzheimer’s drug shows promise in small, early-phase clinical studies
July 12, 2012
Posiphen, a drug candidate designed and developed by researchers in the NIA’s Intramural Research Program, has been shown in three small, early studies to be well-tolerated and to reduce the generation of amyloid and tau protein...
Clinical trials now recruiting
July 11, 2012
Numerous clinical trials and studies are currently recruiting participants with and without Alzheimer's disease, mild cognitive impairment or related dementias. NIA’s Alzheimer’s Disease Education and Referral (ADEAR)...
Exendin-4: From lizard to laboratory... and beyond
July 11, 2012
Throughout history, the natural world has served as a rich resource for compounds to treat human disease. For example, clay tablets from Mesopotamia dating from 2600 B.C.—humanity’s earliest written records—describe the...
Researchers, advocates gather at Summit to accelerate Alzheimer’s research
July 1, 2012
Dr. Francis Collins "We are at an exceptional moment scientifically for Alzheimer's,” declared National Institutes of Health (NIH) Director Dr. Francis Collins before...
CADRO: Common Alzheimer's Disease Research Ontology
June 29, 2012
The creation of the first iteration of the Common Alzheimer Disease Research Ontology (CADRO) is a collaborative effort between the National Institute on Aging (NIA) and the Alzheimer’s Association (AA). The project began in May 2010...
Understanding of mTOR pathway and lifespan refined in new study
June 25, 2012
Investigators have identified interventions that extend lifespan in model systems. For example, caloric restriction (CR) – a reduction in caloric intake while maintaining adequate nutrition – has been shown to increase insulin...
Alzheimer’s Disease Research Summit offers research recommendations
May 18, 2012
The Alzheimer’s Disease Research Summit 2012: Path to Treatment and Prevention, held May 14-15, 2012, brought together leading experts on Alzheimer’s disease and other complex diseases to identify research priorities and...
Genes involved in age-related declines in brain volume may play role in Alzheimer’s disease
April 16, 2012
The hippocampus, a brain region important to learning and memory, gradually loses volume as part of the normal aging process. This loss is significantly accelerated in older people with Alzheimer’s disease, especially if they have...
New study identifies role of large protein fragment in blocking amyloid build-up
April 13, 2012
Plaques made up of abnormal deposits of beta-amyloid protein are a hallmark of Alzheimer’s disease. The toxic buildup begins when the beta-secretase enzyme (BACE), working in concert with a partner enzyme, snips a small fragment of...