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Notice of Intent to Publish a Funding Opportunity Announcement for "Research Planning Infrastructure to Develop Therapeutic Target ID Strategies Based on Favorable Genetic Variants of Human Longevity or Health Span (U24)"

Funding Number: NOT-AG-14-020
Funding Type:
Release Date: July 10, 2014
Expiration Date: January 1, 2017
Web Site: http://grants.nih.gov/grants/guide/notice-files/NOT-AG-14-020.html
Notice Intent Publish Funding Opportunity Announcement Research Planning Infrastructure Develop Therapeutic Target-ID Strategies Based Favorable Genetic Variants Human Longevity Health Span U24)" Notice Number: NOT-AG-14-020 Key Dates Release Date: July 10, 2014 Estimated Publication Date Announcement: August 2014 First Estimated Application Due Date: November 2014  Earliest Estimated Award Date: June 2015  Earliest Estimated Start Date: July 2015 Related Announcements RFA-AG-14-003 Issued National Institute Aging NIA) Purpose National Institute Aging NIA) intends issue Funding Opportunity Announcement FOA) solicit cooperative agreement applications U24) the development research-planning infrastructure multidisciplinary collaborative teams develop target-identification ID) strategies translation potential therapeutic target(s) based genetic factors reliably associated increased human lifespan and/or health span. phrase target-ID strategy" refers a concerted set applied research approaches e.g., additional analyses, required types and sequence studies/experiments methodologies) leading the identification genetic factors, pathways molecules which activities be favorably modified. Notice being provided allow potential applicants sufficient time assemble multidisciplinary team, possible approaches developing research planning infrastructure, meaningful collaborations, responsive projects. FOA expected be published August 2014 an expected application due date November 2014. NIA expects make award the applications submitted response this FOA. FOA utilize U24 activity code. Details the planned FOA provided below. Research Initiative Details Extant research identified both human-genetic variants variants associated protection against age-related chronic diseases favorably influence both longevity risk age. Additional evaluation relations specific lifespan health-span related variants a variety other phenotypes be helpful the identification biological pathways may associated the variant identifying novel therapeutic targets associated human longevity health-span. Effective, coordinated of approaches target-ID strategies based genetic findings related human longevity requires collaboration among several diverse research fields historically rarely interacted. date, such team collaboration exists develop target-ID strategies based human longevity-related genomic findings. anticipated FOA request applications a team will conduct planning activities described the following section) necessary the development target-ID strategies. U24 research-planning infrastructure expected be multidisciplinary collaborative nature sufficient breadth scientific expertise, staff-time commitment, organizational structure, operational procedures leveraging relevant cohort-genetic data performing integrated analyses the selection design the most promising target-ID translation strategies. Core areas expertise should represented the U24 multidisciplinary team include genetics, genomics, epidemiology, research aging, translational genomics, drug development, statistics, bioinformatics. U24 project should conduct following activities: 1. Create integrated database system relevant data, informatics, computational tools assessing effects gene variants analyses identify clarify relations genetic variants increased human longevity health span functional effects these variants; 2. variants strong evidence a relation exceptional human longevity health span, proposed research should evaluate potential utility a basis developing therapeutic target-ID strategies through analyses using system databases informatics/computational tools described above de novo pilot studies. 3. Based evaluations described the second above) activity, applications should develop strategic plan experiments analyses aimed the identification one more therapeutic target(s) interventions the potential extend life span health span. 4. Establish publically-available research resource provides access to, documentation for, computational informatics tools used developed this project, linkages publically-available databases which have used. Although conduct small pilot de novo studies clarify prospects potential strategies e.g., explore functional pathways associated potential targets effects existing drugs affecting such pathways) be included the U24 activities, implementation the target-ID strategies be developed, beyond pilot studies exploratory data analyses, outside scope this FOA.  Support such studies be requested the future through grant mechanisms. New population family studies genetic factors influencing longevity also outside scope this FOA. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Nalini Raghavachari, Ph.D. National Institute Aging NIA) Email: Nalini.raghavachari@nih.gov Telephone: 301-435-3048