Research and Funding

Interventions Testing Program (ITP)

Compounds In Testing

Each material is given in the diet at the following levels (part per million (PPM) by weight).

Cohort 1: C2004
Compound Concentration in food Age at treatment initiation
Aspirin 20 ppm 4 months
NFP 200 ppm 4 months
NDGA 2,500 ppm 9 months
4-OH-PBN 315 ppm 4 months

 

Cohort 2: C2005
Compound Concentration in food Age at treatment initiation
CAPE 30 ppm 4 months
CAPE 300 ppm 4 months
Enalapril Maleate 120 ppm 4 months
Rapamycin 14 ppm 20 month

 

Cohort 3: C2006
Compound Concentration in food Age at treatment initiation
Rapamycin 14 ppm 9 months
Simvastatin 12 ppm 10 months
Simvastatin 120 ppm 10 months
Resveratrol 300 ppm 12 months
Resveratrol 1200 ppm 12 months

 

Cohort 4: C2007
Compound Concentration in food Age at treatment initiation
Resveratrol 300 ppm 4 months
Oxaloacetic acid 2200 ppm 4 months
Green tea extract 2000 ppm 4 months
Curcumin 2000 ppm 4 months
Medium Chain Triglyceride Oil 60000 ppm 4 months

 

Cohort 5: C2009
Compound Concentration in food Age at treatment initiation
17α-Estradiol 4.8 ppm 10 months
Methylene Blue 28 ppm 4 months
Acarbose 1000 ppm 4 months
Rapamycin_LoPhase II 4.7 ppm 9 months
Rapamycin_MidPhase II 14 ppm 9 months
Rapamycin_HiPhase II 42 ppm 9 months

 

Cohort 6: C2010
Compound Concentration in food Age at treatment initiation
Fish Oil 15000 ppm 9 months
Fish Oil 50000 ppm 9 months
NDGA Lo_Phase II 800 ppm 6 months (M only)
NDGA Med_Phase II 2500 ppm 6 months (M only)
NDGA Hi_Phase II 5000 ppm 6 months (M & F)

 

Cohort 7: C2011
Compound Concentration in food Age at treatment initiation
Bile Acids 5000 ppm 5 months
Metformin 1000 ppm 9 months
Metformin + Rapamycin 1000 ppm M + 14 ppm R 9 months
Protandim®  * 600 ppm 10 months
17α-Estradiol 14.4 ppm 10 months

*Protandim® was fed to one group of mice – the Protandim® was increased from 600 ppm to 1200 ppm when the mice reached 17 months of age.

 

Cohort 8: C2012
Compound Concentration in food Age at treatment initiation
INT-767 FXR/TG5R agonist 180 ppm 10 months
Acarbose 1000 ppm 16 months
HBX (2-(2-hydroxyphenyl)-benzoxazole) 1 ppm 15 months
NDGA cross-section study 2500 ppm for Males

5000 ppm for Females
13 months

 

Cohort 9: C2013
Compound Concentration in food Age at treatment initiation
Ursolic Acid 2000 ppm 10 months
FXR agonist INT-747 60 ppm 9 months
Acarbose Phase II 2500 ppm 8 months
Acarbose Phase II 1000 ppm 8 months
Acarbose Phase II 400 ppm 8 months