Ongoing NIA-Funded Clinical Trials

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TABLE 1. Ongoing Alzheimer’s Disease/MCI Prevention Trials Funded by NIA
TRIAL NAME
PRINCIPAL INVESTIGATOR/
INSTITUTION
ANTICIPATED COMPLETION DATE
Nutritional
PREADVISE (Prevention of Alzheimer's Disease by Vitamin E and Selenium)*
Frederick Schmitt, University of Kentucky
2014
AREDS2 (Age-Related Eye Disease Study 2)†
John Paul San Giovanni (Study Director), NEI
2015
Hormones
ELITE (Early Versus Late Intervention with Estradiol)
Howard Hodis, University of Southern California
2014
Cardiovascular
SPRINT-MIND (Systolic Blood Pressure Intervention Trial-MIND)*
David Reboussin, Wake Forest University
2017
ASPREE (Aspirin in Reducing Events in the Elderly)
Richard Grimm, Berman Center for Outcomes & Clinical Research; John McNeil, Monash University
2017
Ihab Hajjar, University of Southern California
2018
Metabolic
Jose Luchsinger, Columbia University
2012
Robert Schwartz, University of Colorado, Denver
2013
Immunotherapy
Eric Reiman, Banner Alzheimer’s Institute
2018
Nonpharmacological
Miriam Mintzer, Johns Hopkins University
2014
Barry Rovner, Thomas Jefferson University
2016
Jennifer Etnier, University of North Carolina at Greensboro
2018

Note: For information on new and currently recruiting trials, visit: www.nia.nih.gov/alzheimers/clinical-trials or www.ClinicalTrials.gov.

*NIA-funded primary prevention add-on trials: PREADVISE (add-on to National Cancer Institute's SELECT trial); SPRINT-MIND (add-on to National Heart, Lung, and Blood Institute's and National Institute of Diabetes and Digestive and Kidney Diseases' SPRINT trial; co-funded with the National Institute of Neurological Disorders and Stroke).

† Co-funded trial: AREDS2 (National Eye Institute, lead institute).

TABLE 2. Ongoing Alzheimer’s Disease/MCI Treatment and Feasibility Clinical Trials Funded by NIA
TRIAL NAME
PRINCIPAL INVESTIGATOR/
INSTITUTION
ANTICIPATED COMPLETION DATE
Treatment Trials—Cognition
Nutritional
Lynne Shinto, Oregon Health & Science University
2014
Nonpharmacological
Jeffrey Burns, University of Kansas
2014
ADMIT (Alzheimer's Disease Multiple Intervention Trial)
Chris Callahan, Indiana University
2016
Grover Gilmore, Case Western Reserve University
2015
Immunotherapy
Norman Relkin, Weill Medical College, Cornell University
2013
Other Interventions
Paul Aisen, University of California, San Diego
2014
R. Scott Turner, Georgetown University
2017
Treatment Trials—Neuropsychiatric Comorbidities
CITAD (Citalopram Treatment for Agitation in Alzheimer Dementia)
Constantine Lyketsos, Johns Hopkins University
2014
Davangere Devanand, New York State Psychiatric Inst./ Columbia University
2015
Elaine Peskind, University of Washington
2013
Laura Gitlin, Johns Hopkins University
2018
Proof of Concept Trials
Cardiovascular
Gail Li, University of Washington
2013
SHARP (Statin Effects on Beta-Amyloid and Cerebral Perfusion in Adults at Risk for Alzheimer’s Disease)
Cynthia Carlsson, University of Wisconsin, Madison
2013
Giulio Maria Pasinetti, Mt. Sinai School of Medicine; Paul Rosenberg, Johns Hopkins University
2015
Hormones
phytoSERM (Phytoserms for Menopause Symptoms and Age-Associated Memory Decline)
Lon Schneider, University of Southern California
2014
Metabolic
Suzanne Craft, University of Washington
2016
Suzanne Craft, University of Washington
2018
Nonpharmacological
AETMCI (Aerobic Exercising Training in MCI)
Rong Zhang & Hanzhang Lu, University of Texas Southwestern Medical Center
2014
Thomas Obisesan, Howard University
2014
LIFE (Lifestyle Interventions and Independence for Elders)
Marco Pahor, University of Florida
2013
Hiroko Dodge, Oregon Health & Science University
2014
Constantine Lyketsos, Johns Hopkins University
2018
Other Interventions
Marwan Sabbagh, Banner Sun Health Research Institute
2014
Yvette Sheline, Washington University
2018

Note: For information on new and currently recruiting trials, visit: www.nia.nih.gov/alzheimers/clinical-trials or www.ClinicalTrials.gov.

*Trial supported through Alzheimer’s Disease Cooperative Study (ADCS)

TABLE 3. Ongoing Age-Related Cognitive Decline Clinical Trials Funded by NIA
TRIAL NAME
PRINCIPAL INVESTIGATOR/
INSTITUTION
ANTICIPATED COMPLETION DATE
Cognitive Training
Mark D'Esposito, University of California, Berkeley
2012
Kristi Multhaup, Davidson College; Mark Faust, University of North Carolina Charlotte
2013
IHAMS (Iowa Healthy and Active Minds Study)
Fredric D. Wolinsky, University of Iowa
2011*
Omega-3 Fatty Acids and Antioxidants
Robert Krikorian, University of Cincinnati
2012
VITAL-Cog (A Large Randomized Trial of Vitamin D, Omega-3 Fatty Acids and Cognitive Decline)
Jae Kang, Brigham and Women's Hospital
2015
Cardiovascular
AVEC (Antihypertensives and Vascular, Endothelial and Cognitive Function Trial)
Ihab Hajjar, University of Southern California
2012
Active Engagement
Denise Park, University of Texas, Dallas
2012
George Rebok, Johns Hopkins University
2011*
Arthur Kramer, University of Illinois, Urbana-Champaign
2015
Elizabeth Stine-Morrow, University of Illinois, Urbana-Champaign
2012
Hormones
Paul Newhouse, Vanderbilt University
2014
Natalie Rasgon, Stanford University
2011*
Yolanda Smith, University of Michigan
2011*
Sanjay Asthana, University of Wisconsin, Madison
2012
Elliot Hirshman, George Washington University
2011*
Peter Snyder, University of Pennsylvania
2015
Metabolic
Shi-jun Jean Hsieh, Albert Einstein College of Medicine, Yeshiva University
2013
Exercise
Yaakov Stern & Richard Sloan, Columbia University
2015
Jeffrey Burns, University of Kansas
2012
Scott Small & Richard Sloan, Columbia University
2015
Exercise and Cognitive Training
Sandra Chapman, University of Texas, Dallas
2011*
Yaakov Stern, Columbia University
2012
EXACT (Combining Exercise and Cognitive Training to Improve Everyday Function)
Ellen Binder & Mark McDaniel, Washington University
2012
Karlene Ball, University of Alabama, Birmingham
2011*
FAST (Fit & Active Seniors Trial)
Arthur Kramer, University of Illinois, Urbana-Champaign
2014
ACE-Seniors (Activities for Cognitive Enhancement of Seniors)
Victor Henderson, Stanford University
2012
Other
Christopher Van Dyck, Yale University
2011*
Manjula Kurella Tamura, Stanford University
2012

Note: For information on new and currently recruiting trials, visit: www.nia.nih.gov/alzheimers/clinical-trials or ClinicalTrials.gov.

*Results are pending for clinical trials completed in 2011.

TABLE 4. Ongoing Delirium Prevention & Treatment Clinical Trials Funded by NIA
TRIAL NAME

PRINCIPAL INVESTIGATOR/
INSTITUTION

ANTICIPATED COMPLETION DATE
Delirium
Malaz Boustani, Indiana University School of Medicine
2015
MIND-USA (The Modifying the Impact of ICU-Associated Neurological Dysfunction-USA Study)
E. Wesley Ely, Vanderbilt University Medical Center
2016
Thomas Robinson, University of Colorado, Denver
2015
STRIDE (Postoperative Delirium in Elderly Surgical Patients)
Frederick Sieber, Johns Hopkins University
2015
Jeffrey Silverstein, Mt. Sinai School of Medicine
2012

Note: For information on new and currently recruiting trials, visit: www.nia.nih.gov/alzheimers/clinical-trials or ClinicalTrials.gov.