Alzheimer's Disease Education and Referral Center

Aspirin in Reducing Events in the Elderly (ASPREE)

Aspirin in Reducing Events in the Elderly (ASPREE)

Overall Status: 
Recruiting
Brief Description: 

The ASPREE study will examine whether the potential benefits of low-dose aspirin (particularly preventing heart disease, stroke, certain cancers, and dementia) outweigh the risks (particularly bleeding) in people over age 70. ASPREE will determine whether taking a daily low-dose aspirin will extend the length of a disability-free life in healthy participants aged 70 years and above.

Patient Qualifications: 
Min AgeGenderHealthy Volunteers
70 Years
Both
Accepts Healthy Volunteers
Inclusion Criteria: 

  • Men and women 70 years of age and over

Exclusion Criteria: 

  • History of a diagnosed cardiovascular event
  • Serious intercurrent illness likely to cause death within the next 5 years, such as terminal cancer or obstructive airways disease
  • Current or recurrent condition with a high risk of major bleeding, for example, cerebral aneurysm
  • Anemia
  • Current participation in a clinical trial
  • Systolic blood pressure of ≥180 mmHg and/or diastolic blood pressure of ≥105 mmHg
  • History of dementia
  • Severe difficulty or inability to perform any one of the 6 Katz activities of daily living
  • Noncompliance to taking pill
  • Absolute contraindication or allergy to aspirin
  • Current continuous use of aspirin or other antiplatelet drug or anticoagulant for secondary prevention; people with previous use of aspirin for primary prevention may enter the trial, provided they agree to cease existing use of aspirin and understand that they may be subsequently randomly allocated to low-dose aspirin or placebo

Detailed Description: 

Low-dose aspirin therapy has been shown to reduce the risk of vascular events, largely in middle-aged people. There is also some evidence of its potential to reduce the rate of intellectual decline and certain types cancers in older participants. However, these benefits may be offset by adverse effects, such as potential bleeding. The balance of risks and benefits of low-dose aspirin has not been established in older persons. Previous studies on the effects of aspirin in primary prevention have mainly focused on cardiovascular outcomes. In the elderly, these outcomes alone may not be the most appropriate measure of benefit associated with aspirin treatment. Prolonging a life free of functional disability in a healthy aging population would be the most desirable benefit of aspirin as a preventive medicine.

Central Contact Information: 

If you are interested in joining ASPREE, please contact a location near you from the list below. For more information about this trial, visit the ASPREE website.

Locations: 
Map Marker CityStateZip CodeStatusPrimary Contact

Geolocation is 33.5075555, -86.8093239

Birmingham
Alabama
35294
Recruiting
Name:
Phone:

Geolocation is 37.4457966, -122.1575745

Palo Alto
California
94301
Recruiting
Name:
Phone:

Geolocation is 38.9178427, -77.0218255

Washington
District of Columbia
20060
Recruiting
Name:
Phone:

Geolocation is 29.6130239, -82.371937

Gainsville
Florida
32611
Recruiting
Name:
Phone:

Geolocation is 33.7980995, -84.3259367

Atlanta
Georgia
30322
Recruiting
Name:
Phone:

Geolocation is 33.7321902, -84.4225186

Atlanta
Georgia
30310
Recruiting
Name:
Phone:

Geolocation is 33.474324, -81.9899547

Augusta
Georgia
30912
Recruiting
Name:
Phone:

Geolocation is 41.8816606, -87.6926257

Chicago
Illinois
60612
Recruiting
Name:
Phone:

Geolocation is 41.659363, -91.5487099

Iowa City
Iowa
52242
Recruiting
Name:
Phone:

Geolocation is 39.0704366, -94.6967189

Kansas City
Kansas
66106
Recruiting
Name:
Phone:

Geolocation is 30.4192451, -91.1448981

Baton Rouge
Louisiana
70808
Recruiting
Name:
Phone:

Geolocation is 30.3911214, -91.0634024

Baton Rouge
Louisiana
70809
Recruiting
Name:
Phone:

Geolocation is 30.4483779, -91.188708

Baton Rouge
Louisiana
70801
Recruiting
Name:
Phone:

Geolocation is 30.4754702, -90.1009108

Covington
Louisiana
70433
Recruiting
Name:
Phone:

Geolocation is 29.5957696, -90.7195348

Houma
Louisiana
70360
Recruiting
Name:
Phone:

Geolocation is 29.9595769, -90.0770127

New Orleans
Louisiana
70112
Recruiting
Name:
Phone:

Geolocation is 29.9595769, -90.0770127

New Orleans
Louisiana
70112
Recruiting
Name:
Phone:

Geolocation is 32.49, -93.77

Shreveport
Louisiana
71130
Recruiting
Name:
Phone:

Geolocation is 42.3053253, -83.6694169

Ann Arbor
Michigan
48109
Recruiting
Name:
Phone:

Geolocation is 42.3664506, -83.0737195

Detroit
Michigan
48202
Active, not recruiting
Name:
Phone:

Geolocation is 42.348495, -83.0602998

Detroit
Michigan
48201
Recruiting
Name:
Phone:

Geolocation is 42.5123116, -83.4750241

Novi
Michigan
48377
Recruiting
Name:
Phone:

Geolocation is 44.851048, -93.2395012

Minneapolis
Minnesota
55425
Recruiting
Name:
Phone:

Geolocation is 44.9687549, -93.0485951

St. Paul
Minnesota
55106
Recruiting
Name:
Phone:

Geolocation is 40.6517521, -74.2149978

Elizabeth
New Jersey
07202
Recruiting
Name:
Phone:

Geolocation is 40.7383636, -74.197388

Newark
New Jersey
07103
Recruiting
Name:
Phone:

Geolocation is 40.6515882, -73.9330429

Brooklyn
New York
11203
Recruiting
Name:
Phone:

Geolocation is 40.7492678, -73.6406845

Mineola
New York
11501
Recruiting
Name:
Phone:

Geolocation is 40.7154518, -73.7919103

Queens
New York
11432
Recruiting
Name:
Phone:

Geolocation is 36.1046869, -79.8128649

Greensboro
North Carolina
27408
Recruiting
Name:
Phone:

Geolocation is 35.612661, -77.3663538

Greenville
North Carolina
27834
Recruiting
Name:
Phone:

Geolocation is 40.0397682, -75.145782

Philadelphia
Pennsylvania
19141
Recruiting
Name:
Phone:

Geolocation is 40.4424402, -79.9531948

Pittsburgh
Pennsylvania
15260
Recruiting
Name:
Phone:

Geolocation is 41.8684902, -71.3883751

Pawtucket
Rhode Island
02860
Recruiting
Name:
Phone:

Geolocation is 35.1516237, -90.0349866

Memphis
Tennessee
38105
Recruiting
Name:
Phone:

Geolocation is 36.1632339, -86.7823835

Nashville
Tennessee
57208
Recruiting
Name:
Phone:

Geolocation is 32.8113367, -96.8397899

Dallas
Texas
75390
Recruiting
Name:
Phone:

Geolocation is 29.3106102, -94.7772493

Galveston
Texas
77555
Recruiting
Name:
Phone:

Geolocation is 26.1906306, -97.6961026

Harlingen
Texas
78550
Recruiting
Name:
Phone:

Geolocation is 29.5060908, -98.577596

San Antonio
Texas
78229
Recruiting
Name:
Phone:
Lead Sponsor: 
Agency
Minneapolis Medical Research Foundation
Collaborator Sponsor: 
Agency
National Health and Medical Research Council, Australia
Bayer
Monash University
Berman Center for Outcomes and Clinical Research
Facility Investigators: 
NameRoleAffiliation
Richard Grimm, MD, PhD
Principal Investigator
Berman Center for Outcomes and Clinical Research
John McNeil, MD
Principal Investigator
Monash University
Study Contact: 
NamePhoneEmail
Nathan J. Tessum
612-341-7907
Brenda Kirpach
612-341-7922
Locations
 
 
ClinicalTrials.gov ID 
NCT01038583 (follow link to view full record on ct.gov in new window)
Official Title: 
Aspirin in Reducing Events in the Elderly
Study Start Date: 
January 2010
Study End Date: 
August 2016
Enrollment: 
19000