Alzheimer's Disease Education and Referral Center

Alzheimer's Disease Multiple Intervention Trial

Alzheimer's Disease Multiple Intervention Trial

Overall Status: 
Recruiting
Brief Description: 

The purpose of this study is to conduct a 2-year, randomized, controlled clinical trial to improve functioning among older adults with Alzheimer's disease. The trial will compare a control group receiving best practices primary care with an intervention group receiving best practices primary care plus a home-based occupational therapy intervention.

Patient Qualifications: 
Min AgeMax AgeGenderHealthy Volunteers
45 Years
N/A
Both
No
Inclusion Criteria: 

    Participants

  • Current patient at Wishard Health Services in central Indiana
  • Diagnosis of possible or probable Alzheimer's disease
  • Age 45 or older
  • English speaking
  • Hearing adequate to answer questions in person or by telephone
  • Community-dwelling (includes senior communities but not skilled nursing facilities)
  • Caregiver willing to participate in the study
  • Willing to receive home visits
  • Live in Indianapolis metro area and are planning to continue care at a primary care clinic

    Caregivers

  • Age 18 or older
  • English speaking
  • Hearing adequate to answer questions in person or by telephone
  • Community-dwelling
  • Willing to receive home visits

Exclusion Criteria: 

  • Not a current patient at Wishard Health Services
  • Non-English speaking
  • Currently enrolled in another study
  • Non-community dwelling or residing in a skilled nursing facility

Detailed Description: 

The current study will test a home-based intervention designed to slow the rate of functional decline among older adults with Alzheimer's disease. A previous clinical trial demonstrated the effectiveness of collaborative primary care for older adults with Alzheimer's. In the prior trial, guideline-level medical care resulted in improved quality of care and improved behavioral and psychological symptoms over 1 year among patients and their caregivers. Despite significant differences among study groups on neuropsychiatric test scores, no significant difference  in functional decline was found between groups. Both study groups experienced a significant decline in function over 18 months.

This study also builds on recently reported research that demonstrated the short-term efficacy of home-based occupational therapy among older adults with dementia. These trials showed that older adults with dementia, including Alzheimer's disease, can both participate in and benefit from occupational therapy-based interventions delivered in the home.

Locations: 
Map Marker CityStateZip CodeStatusPrimary Contact

Geolocation is 39.7794767, -86.1700894

Wishard Health Services
Indianapolis
Indiana
46202
Recruiting
Name: Carrie S. Morris, MS, OTR
Phone: 317-423-5639
Email: cespangl@iupui.edu
Lead Sponsor: 
Agency
Regenstrief Institute, IU Center for Aging Research
Collaborator Sponsor: 
Agency
National Institute on Aging (NIA)
Facility Investigators: 
NameRoleAffiliation
Christopher M Callahan, MD
Principal Investigator
Indiana University School of Medicine
Study Contact: 
NamePhoneEmail
Carrie S. Morris, MS, OTR
317-423-5639
Locations
 
 
ClinicalTrials.gov ID 
NCT01314950 (follow link to view full record on ct.gov in new window)
Official Title: 
Alzheimer's Disease Multiple Intervention Trial
Study Start Date: 
July 2010
Study End Date: 
June 2015
Enrollment: 
180